PURPOSE: To evaluate the effects of social support on comprehension and recall of consent form information in a study of Parkinson disease patients and their caregivers.DESIGN and METHODS: Comparison of comprehension and recall outcomes among participants who read and signed the consent form accompanied by a family member/friend versus those of participants who read and signed the consent form unaccompanied. Comprehension and recall of consent form information were measured at one week and one month respectively, using Part A of the (...) Quality of Informed Consent Questionnaire .RESULTS: The mean age of the sample of 143 participants was 71 years . Analysis of covariance was used to compare QuIC scores between the intervention group and control group . In the 1-week model, no statistically significant intervention effect was found . However, the intervention status by patient status interaction was statistically significant . In the 1-month model, no statistically significant intervention effect was found . Again, however, the intervention status by patient status interaction was statistically significant . At both time periods, intervention group patients scored higher on the QuIC than did intervention group caregivers, and control group patients scored lower on the QuIC than did control group caregivers.IMPLICATIONS: Social support played a significant role in enhancing comprehension and recall of consent form information among patients. (shrink)

Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)

The task of this chapter is to investigate and assess Grossmann’s view of the ontological status of categories. It has two dimensions. Because Grossmann does not offer a full discussion of the ontology of categories, we first need to present an interpretation of his view. Our point of departure is Grossmann’s claim that a category is a fundamental property of being (which implies that he holds view 3 above). Our second task is to assess the adequacy of his view. We (...) do this by raising some problems with Grossmann’s account, offering as an alternative view a version of 4 above, and defending it against what we construe as Grossmann’s possible counter-arguments. We argue that the best way to view categories themselves is as ontologically neutral insofar as this opens the way for particular categories to be linguistic entities, mental acts, or properties of extra-mental things. This requires, in turn, a qualified defense of two views rejected by Grossmann—common natures and modes of being. (shrink)

Limits to Action: The Allocation of Individual Behavior presents the ideas and methods in the study of how individual organisms allocate their limited time and energy and the consequences of such allocation. The book is a survey of individual resource allocation, emphasizing the relationships of the concepts of utility, reinforcement, and Darwinian fitness. The chapters are arranged beginning with plants and general evolutionary considerations, through animal behavior in nature and laboratory, and ending with human behavior in suburb and institution. Topics (...) discussed include operant conditioning; the principle of diminishing returns; and issues in relation to mating strategies. Biologists, sociologists, economists, and psychologists will find the book interesting. (shrink)

This unique collection of essays, published together for the first time, not only elucidates the complexity of ancient Greek thought, but also reveals Karl Popper's engagement with Presocratic philosophy and the enlightenment he experienced in his reading of Parmenides. As Karl Popper himself states himself in his introduction, he was inspired to write about Presocratic philosophy for two reasons - firstly to illustrate the thesis that all history is the history of problem situations and secondly, to show the greatness of (...) the early Greek philosophers, who gave Europe its philosophy, its science and its humanism. (shrink)

This unique collection of essays not only explores the complexity of ancient Greek thought, but also reveals Popper's engagement with Presocratic philosophy and the enlightenment he experienced in reading Parmenides. It includes writings on Greek science, philosophy and history, and demonstrates Popper's lifelong fascination and admiration of the Presocratic philosophers, in particular Parmenides, Xenophanes and Heraclitus.

This unique collection of essays, published together for the first time, not only elucidates the complexity of ancient Greek thought, but also reveals Karl Popper's engagement with Presocratic philosophy and the enlightenment he experienced in his reading of Parmenides. As Karl Popper himself states himself in his introduction, he was inspired to write about Presocratic philosophy for two reasons - firstly to illustrate the thesis that all history is the history of problem situations and secondly, to show the greatness of (...) the early Greek philosophers, who gave Europe its philosophy, its science and its humanism. (shrink)

What are physical quantities, and in particular, what makes them quantitative? This book presents an original answer to this question through the novel position of substantival structuralism, arguing that quantitativeness is an irreducible feature of attributes, and quantitative attributes are best understood as substantival structured spaces.

Analogies must be symmetric. If a is like b, then b is like a. So if a has property R, and if R is within the scope of the analogy, then b (probably) has R. However, analogical arguments generally single out, or depend upon, only one of a or b to serve as the basis for the inference. In this respect, analogical arguments are directed by an asymmetry. I defend the importance of this neglected – even when explicitly mentioned – (...) feature in understanding analogical arguments. (shrink)

It may seem strange, in view of the spate of recent literature on the subject, that yet another article should be forthcoming on what is certainly the most familiar, as well as the most vexed, of all Platonic passages. But it is precisely this spate of literature that has impelled me to write. The time seems to have come for an article which, rather than seeking desperately for something new, sets out instead to reaffirm those facts and conclusions that even (...) the most resolutely original of scholars could hardly venture to dispute. This article will therefore be based, not on any of the numerous modern interpretations, but on what Plato himself actually wrote. It will contain a number of tentative suggestions which, to the best of my knowledge, have not been made before. They can, and probably will, be rejected. But its primary purpose remains to restate, whenever possible in Plato's own words, a number of important facts that are at once so simple and so obvious that they seem repeatedly, and especially in recent years, to have been quite forgotten. (shrink)

This book is an anthology of Plato's writings, connected with sections of commentary.

In a well-known quotation from Speusippus in the Theologumena Arithmeticae , said to have been derived from Pythagorean sources, especially Philolaus, occur the following sentences: And again a little later: Similarly Sextus Empiricus , drawing evidently on a relatively early Pythagorean source, writes as follows: And Aristotle himself writes of the Pythagoreans : There were, in fact, certain Pythagoreans who equated the number 2 with the line because they regarded the line as ‘length without breadth extended between two points’; and (...) likewise the number 3 was equated with the plane and 4 with the solid. (shrink)

'To think often, and never to retain it so much as one moment, is a very useless sort of thinking' In An Essay concerning Human Understanding, John Locke sets out his theory of knowledge and how we acquire it. Eschewing doctrines of innate principles and ideas, Locke shows how all our ideas, even the most abstract and complex, are grounded in human experience and attained by sensation of external things or reflection upon our own mental activities. A thorough examination of (...) the communication of ideas through language and the conventions of taking words as signs of ideas paves the way for his penetrating critique of the limitations of ideas and the extent of our knowledge of ourselves, the world, God, and morals. Locke's masterpiece laid the foundation of British empiricism and is of enduring interest to anyone exploring the development of philosophical thought. This sensitive abridgement uses P. H. Nidditch's authoritative text, and together with an illuminating introduction and other features, makes Locke's arguments more accessible. (shrink)

No pre-Socratic philosopher, perhaps, has caused more disagreement, or been more variously interpreted, than Anaxagoras of Clazomenae. Among recent attempts to reconstruct his system some of the more notable are those of Tannery, Bailey, Cornford, Peck, and Vlastos. Each of these reconstructions, and especially that of Tannery, has its adherents; and since none of them has much in common with any other, a universally acceptable solution to the fundamental problems involved may well by now seem unattainable. It is my belief, (...) however, and it is the object of this paper to try to prove, that all these modern reconstructions have at least one quality in common, namely an undue complication. The actual system of Anaxagoras was, I believe, considerably simpler than any reconstruction yet forthcoming. Unfortunately what I take to be the basis of the whole system, Anaxagoras' reaction to his Eleatic predecessors, is by.no means easy to convey in brief and simple terms. But if I should succeed in conveying it, then it will, I hope, be seen in itself to possess such a simplicity and neatness that my contention will carry with it a fair warrant of its own truth. I shall, for convenience, divide my argument into ten sections, to which I shall append a brief summary of my conclusions. (shrink)

It is standardly assumed that there are three — and only three — ways to solve problem of temporary intrinsics: (a) embrace presentism, (b) relativize property possession to times, or (c) accept the doctrine of temporal parts. The first two solutions are favoured by endurantists, whereas the third is the perdurantist solution of choice. In this paper, I argue that there is a further type of solution available to endurantists, one that not only avoids the usual costs, but is structurally (...) identical to the temporal-parts solution preferred by perdurantists. In addition to providing a general characterization of this new type of solution, I discuss certain of its anticipations in the literature on bundle theory, as well as provide a detailed development of it in terms of my own preferred metaphysics of ordinary objects — namely, a distinctive form of substratum theory tracing to Aristotle. (shrink)

Manuscript Add. 3965, section 13, folios 541r–542r and 545r–546r is in the Portsmouth Collection of manuscripts and housed in the University Library, Cambridge. These drafts contain a careful account, in Newton's hand, of his views on place, time, and God. They are part of a large number of drafts relating to the three official editions of the Principia published in Newton's lifetime.

In a well-known quotation from Speusippus in the Theologumena Arithmeticae, said to have been derived from Pythagorean sources, especially Philolaus, occur the following sentences: And again a little later: Similarly Sextus Empiricus, drawing evidently on a relatively early Pythagorean source, writes as follows: And Aristotle himself writes of the Pythagoreans : There were, in fact, certain Pythagoreans who equated the number 2 with the line because they regarded the line as ‘length without breadth extended between two points’; and likewise the (...) number 3 was equated with the plane and 4 with the solid. (shrink)

Measurement realism, the view that measurement targets quantitative attributes and that not all attributes are quantitative, has come under attack both from metrologists and philosophers. In this paper, I take a close look at two influential arguments against measurement realism: the argument from obsolescence and the argument from coordination. I concede that these arguments do challenge the epistemological position traditionally taken by measurement realists, but argue that the metaphysical core of measurement realism survives the challenge posed by these arguments. This (...) metaphysical core is vital to maintaining a clear and ambitious standard for successful measurement. (shrink)

This study considers Newton's views on space and time with respect to some important ontologies of substance in his period. Specifically, it deals in a philosophico-historical manner with his conception of substance, attribute, existence, to actuality and necessity. I show how Newton links these “features” of things to his conception of God's existence with respect of infinite space and time. Moreover, I argue that his ontology of space and time cannot be understood without fully appreciating how it relates to the (...) nature of Divine existence. In order to establish this, the ontology embodied in Newton's theory of predication is analysed, and shown to be different from the presuppositions of the ontological argument. From the historical point of view Gassendi's influence is stressed, via the mediation of Walter Charleton. Furthermore, Newton's thought on these matters is contrasted with Descartes's and Spinoza's. In point of fact, in his earliest notebook Newton recorded observations on Descartes's version of the ontological argument. Soon, however, he was to oppose the Cartesian conception of the actuality of Divine existence by means of arguments similar to those of Gassendi. Lastly, I suggest that the nature and extent of Henry More's influence on Newton's conception of how God relates to absolute space and time bears further examination. (shrink)

The subject is in both cases the voyage of the Argo, and therefore the use of the same words is not likely to be coincidental, even though the words themselves are scarcely uncommon. One would hesitate to deny, however, that such reminiscence might be unconscious; that Lucan had famous tags in his head is suggested by another allusion to famous opening lines.

Potential ethical issues can arise during the process of epidemiological classification. For example, unnatural infant deaths are classified as accidental deaths or homicides. Societal sensitivity to the physical abuse and neglect of children has increased over recent decades. This enhanced sensitivity could impact reported infant homicide rates. Infant homicide and accident mortality rates in boys and girls in the USA from 1940 to 2005 were analysed. In 1940, infant accident mortality rates were over 20 times greater than infant homicide rates (...) in both boys and girls. After about 1980, when the ratio of infant accident mortality rates to infant homicide rates decreased to less than five, and the sum of infant accident and homicide rates became relatively constant, further decreases in infant accident mortality rates were associated with increases in reported infant homicide rates. These findings suggest that the dramatic decline of accidental infant mortality and recent increased societal sensitivity to child abuse may be related to the increased infant homicide rates observed in the USA since 1980 rather than an actual increase in societal violence directed against infants. Ethical consequences of epidemiological classification, involving the principles of beneficence, non-maleficence and justice, are suggested by observed patterns in infant accidental deaths and homicides in the USA from 1940 to 2005. (shrink)

Recent literature on causation invokes a distinction between deviant and default behavior to account for token causation. Critical examination of two prominent attempts to employ a distinction between deviants and defaults reveals that the distinction is far from clear. I clarify and develop the distinction by appeal to the notion of a modally robust process, and show how the distinction can be employed by causal process theorists to respond to cases of causation by omission. This shows that the default/deviant distinction (...) is not so much a tool for counterfactual accounts of causation, but rather for causal process theory. (shrink)